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Toxicities and outcomes in metastatic melanoma patients (pts) treated with Ipilimumab (Ipi) and BRAF inhibitors (BRAFi). Ann Oncol 28(2):368-376, 2017. e-Pub 2016. Ann Surg 257(4):731-6, 2013. Cancer 123(8):1372-1381, 2017. e-Pub 2016. Cooper ZA, Frederick DT, Juneja VR, Sullivan RJ, Lawrence DP, Piris A, Sharpe AH, Fisher DE, Flaherty KT. PMID: 32491160. . Patient Characteristics Associated With ≥ 36-month Clinical Benefit With Combination Dabrafenib and Trametinib in COMBI-d. ESMO 2016 Scientific, 2016. . Science. Clin Cancer Res 26(6):1258-1266. e-Pub 2020. Correlation of BRAF and NRAS mutation status with tumor characteristics and treatment outcomes in melanoma patients with brain metastasis. Log in to our secure, personalized website to manage your care (formerly myMDAnderson). Stockman D, Tetzlaff MT, Al-Zaid T, Torres-Cabala CA, Bucheit AD, Lazar AJF, Sui D, Jakob JA, Bassett R, Prieto VG. Prevalence of incidental actionable germline mutations in 1,000 advanced cancer patients on a prospective somatic genomic profiling program. Results: The clinical pathway affected all cost outcome measures. Cancer Discov 4(10):1214-29, 2014. Dr. Wargo was recruited to the Division of Surgical Oncology at Massachusetts General Hospital in July 2008 and had an active research laboratory focusing on melanoma tumorigenesis and immunotherapy for cancer. Cancer Res 78(19):5680-5693, 2018. e-Pub 2018. Forget MA, Haymaker C, Hess KR, Meng YJ, Creasy C, Karpinets T, Fulbright OJ, Roszik J, Woodman SE, Kim YU, Sakellariou-Thompson D, Bhatta A, Wahl A, Flores E, Thorsen ST, Tavera RJ, Ramachandran R, Gonzalez AM, Toth CL, Wardell S, Mansaray R, Patel V, Carpio DJ, Vaughn C, Farinas CM, Velasquez PG, Hwu WJ, Patel SP, Vishnoi M, Boral D, Liu H, Sprouse ML, Yin W, Goswami-Sewell D, Tetzlaff MT, Davies MA, Oliva ICG, Marchetti D. Tetzlaff MT, Messina JL, Stein JE, Xu X, Amaria RN, Blank CU, van de Wiel BA, Ferguson PM, Rawson RV, Ross MI, Spillane AJ, Gershenwald JE, Saw RPM, van Akkooi ACJ, van Houdt WJ, Mitchell TC, Menzies AM, Long GV, Wargo JA. Before moving to full time teaching, Nina acted as charge nurse, nurse preceptor, and staff nurse. PMID: 22968073. . PMID: 25068011. . e-Pub 2020. Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study. Differential patterns of leukocyte infiltrate at progression on targeted therapy versus immunotherapy for melanoma. PMID: 27141370. . B7-H3 expression in Merkel cell carcinoma-associated endothelial cells correlates with locally aggressive primary tumor features and increased vascular density. Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to Anti-CTLA-4 therapy. PMID: 29873738. . PMID: 26819345. . Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials. Converts paper pathways into actionable workflows inside of Epic Systems and Cerner that help providers assess, diagnose, manage and treat patients. He is a Professor of Orthopedic Surgery at Weill Cornell Medical College. Nagarajan P, Piao J, Ning J, Noordenbos LE, Curry JL, Torres-Cabala CA, Diwan AH, Aung PA, Ivan D, Ross MI, Royal RE, Wargo JA, Wang WL, Samdani R, Lazar AJ, Rashid A. Carapeto FCL, Fischer GM, Joon AY, Chen H, Haydu L, Lee S, Saul M, Appana S, Thompson JF, Mann GJ, McQuade JL, Lazar AJ, Kirkwood J, Scolyer RA, Long GV. ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma. 2019 SMR Congress, 2019. . AACR Special Conference on Melanoma: From Biology to Target, 2019. . AACR Annual Meeting, 2007. . Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma. PMID: 22850568. . Treatment with chromatin remodeling agents increases MAGE-A3 expression in pancreatic cancer and enhances antigen-specific recognition by T lymphocytes. PDK1 and SGK3 contribute to the growth of BRAF mutant melanomas and are potential therapeutic targets. Member, Molecular Testing Task Force, 2010 - Present. Nitric oxide (NO) production by splenocytes is increased after bile duct ligation (BDL) in the rat. Patient derived xenograft (PDX) of human melanoma to predict clinical responses. Science 368(6494):973-980, 2020. PMID: 30026332. . Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment: a pooled analysis of individual patient data from randomised trials. PMID: 28733428. . Upregulation of Cell Surface GD3 Ganglioside Phenotype Associates with Human Melanoma Brain Metastasis. PMID: 26014291. . PMID: 23171796. . The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma. Eriksson H, Hansson J, Krynitz B, Masucci G, Girnita A, Lapins J, Huen AO, Tawbi HA. J Natl Cancer Inst 108(6):djv426, 2016. e-Pub 2016. Cancer Discov 7(10):1088-1097, 2017. e-Pub 2017. Characteristics of patients (pts) with a complete response (CR) treated with dabrafenib plus trametinib (D+T) combination therapy: findings from COMBI-d and COMBI-v 5-year analysis. PMID: 24185007. . PMID: 26096933. . Society for Melanoma Research (SMR) 2018 Meeting, Manchester, England, 2018. . Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma. PMID: 31398337. . Interferon-gamma (IFN-y) stimulates release of nitric oxide (NO) in macrophages primed by bile duct ligation. Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood. Anderson SPORE in Melanoma – Core B: Melanoma Clinical Database, Tissue Resource, and Translational Pathology Core, UT M.D. Patterns of immune infiltrate differ at progression on targeted therapy versus immune checkpoint blockade for melanoma. Learn about clinical trials at MD Anderson and search our database for open studies. Pigment Cell Melanoma Res 32(3):458-469, 2019. e-Pub 2019. Galloway-Peña JR, Smith DP, Sahasrabhojane P, Ajami NJ, Wadsworth WD, Daver NG, Chemaly RF, Marsh L, Ghantoji SS, Pemmaraju N, Garcia-Manero G, Rezvani K, Alousi AM. Clinicopathological features and clinical outcomes associated with TP53 and BRAF (Non-V600) mutations in cutaneous melanoma patients. Szczepaniak Sloane RA, Gopalakrishnan V, Reddy SM, Zhang X, Reuben A. Reuben A, Petaccia de Macedo M, McQuade J, Joon A, Ren Z, Calderone T, Conner B, Wani K, Cooper ZA, Tawbi H, Tetzlaff MT, Padera RF, Durand JB, Lazar AJ. PMID: 28442307. . MD Anderson houses one of the largest, most developed cancer prevention programs in the nation, conducting research to assess and manage cancer risk through early detection, genetic counseling and clinical interventions, and implementing prevention programs that include genetic testing, chemoprevention, behavioral and nutritional counseling. Drug repurposing screen using BTAFi/MEKi- and immunotherapy-resistant PDX identifies salvage strategies. 2010 ASCO Annual Meeting, 2010. . One of the methods of internal cost control has been the use of clinical pathways. Gene expression profiling of lichenoid dermatitis immune-related adverse event from immune checkpoint inhibitors reveals increased CD14+ and CD16+ monocytes driving an innate immune response. Ocular melanoma metastatic to the pancreas after a 28-year disease-free interval. Your account has been temporarily locked. Fang S, Sui D, Wang Y, Liu H, Chiang YJ, Ross MI, Gershenwald JE, Cormier JN, Royal RE, Lucci A. Zhang G, Frederick DT, Wu L, Wei Z, Krepler C, Srinivasan S, Chae YC, Xu X, Choi H, Dimwamwa E, Ope O, Shannan B, Basu D, Zhang D, Guha M, Xiao M, Randell S, Sproesser K, Xu W, Liu J, Karakousis GC, Schuchter LM, Gangadhar TC, Amaravadi RK, Gu M, Xu C, Ghosh A, Xu W, Tian T, Zhang J, Zha S, Liu Q, Brafford P, Weeraratna A, Davies MA. Natural killer cells play a critical role in the immune response following immunization with melanoma-antigen-engineered dendritic cells. Cancer. BMC Cancer 18(1):913, 2018. . Nat Med 18(10):1503-10, 2012. e-Pub 2012. J Clin Anesth 19(6):479-81, 2007. treatments that cannot be found anywhere else. Friedman AA, Amzallag A, Pruteanu-Malinici I, Baniya S, Cooper ZA, Piris A, Hargreaves L, Igras V, Frederick DT, Lawrence DP, Haber DA, Flaherty KT. Choose from 12 allied health programs at School of Health Professions. Presented at the annual meeting of the Association for Academic Surgery, 1998. . ASCO Annual Meeting 2017, 2017. . PMID: 29848573. . Evaluating Circulating Tumor DNA From the Cerebrospinal Fluid of Patients With Melanoma and Leptomeningeal Disease. Ballester LY, Glitza Oliva IC, Douse DY, Chen MM, Lan C, Haydu LE, Huse JT, Roy-Chowdhuri S, Luthra R, Wistuba II. 2018 SMR International Congress Meeting, 2018. . Biological Validation of RNA Sequencing Data From Formalin-Fixed Paraffin-Embedded Primary Melanomas. PMID: 29945191. . Oncologist 25(3):e602-e605, 2020. e-Pub 2019. Degree-Granting Education. Toxicity of Immune Checkpoint Inhibitors: Considerations for the Surgeon. Journal of Investigative Dermatology. PMID: 23657686. . Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR. A Phase 2, open-label, randomized, multicenter trial of Encorafenib + Binimetinib evaluating a standard-dose and a high-dose regimen in patients with BRAFV600-mutant melanoma brain metastasis (MBM) (POLARIS). Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma. Radiother Oncol 125(1):80-88, 2017. e-Pub 2017. In addition to providing standard of care therapies, he has designed and led multiple clinical trials for patients with advanced melanoma. Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma. PMID: 29776954. . Your gift will help support our mission to end cancer and make a difference in the lives of our patients. e-Pub 2016. Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma. PMID: 31146499. . Farah M, Nagarajan P, Torres-Cabala CA, Curry JL, Amaria RN. Nature, 2020. e-Pub 2020. J Gastrointest Surg 18(1):137-44; discussion 144-5, 2014. e-Pub 2013. An exercise oncology clinical pathway: Screening and referral for personalized interventions - Stout - 2020 - Cancer - … Rohlfs, M, Bassett RL, Lacey C, McQual N, Mehta U, John I, Simien R, Tupue S, Dett TK, Glitza IC, Diab A, Amaria RN, Tawbi HAH. Translational Advances in Radiation Oncology and Cancer Imaging Symposium, 2008. . PMID: 24096750. . Amaria RN, Cooper ZA, Chen P, Boland, G, Davies MA, Ross MI, Tetzlaff MT. Qin Y, Petaccia de Macedo M, Reuben A, Forget MA, Haymaker C, Bernatchez C, Spencer CN, Gopalakrishnan V, Reddy S, Cooper ZA, Fulbright OJ, Ramachandran R, Wahl A, Flores E, Thorsen ST, Tavera RJ, Conrad C, Williams MD, Tetzlaff MT, Wang WL, Gombos DS, Esmaeli B, Amaria RN, Hwu P. Reuben A, Spencer CN, Prieto PA, Gopalakrishnan V, Reddy SM, Miller JP, Mao X, De Macedo MP, Chen J, Song X, Jiang H, Chen PL, Beird HC, Garber HR, Roh W, Wani K, Chen E, Haymaker C, Forget MA, Little LD, Gumbs C, Thornton RL, Hudgens CW, Chen WS, Austin-Breneman J, Sloane RS, Nezi L, Cogdill AP, Bernatchez C, Roszik J, Hwu P, Woodman SE, Chin L, Tawbi H, Davies MA, Gershenwald JE, Amaria RN, Glitza IC, Diab A, Patel SP, Hu J, Lee JE, Grimm EA, Tetzlaff MT, Lazar AJ, Wistuba II, Clise-Dwyer K, Carter BW, Zhang J, Futreal PA, Sharma P, Allison JP, Cooper ZA. Your gift will help support our mission to end cancer and make a difference in the lives of our patients. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Clinical pathway of primary lung cancer suegery (2013 edition) Xiuyi Zhi, Jianxing He, Hui Li, Xun Zhang, Gening Jiang, Heng Zhao, Lunxu Liu, Deruo Liu, Shanqing Li, Jian Li, Qinghua Zhou, Qun Wang, Ruwen Wang, Jianhua Fu, Lin Xu, Linyou Zhang, Naikang Zhou, Shaofa Xu, Donghong Chen. J Invest Dermatol 137(8):1792-1795, 2017. e-Pub 2017. Krepler C, Sproesser K, Brafford P, Beqiri M, Garman B, Xiao M, Shannan B, Watters A, Perego M, Zhang G, Vultur A, Yin X, Liu Q, Anastopoulos IN, Wubbenhorst B, Wilson MA, Xu W, Karakousis G, Feldman M, Xu X, Amaravadi R, Gangadhar TC, Elder DE, Haydu LE. A Multicenter Phase (Ph) 1b Randomized, Double Blind, Placebo (PBO)- Controlled Study to Evaluate the Safety, Tolerability and Efficacy of Microbiome Study Intervention (MSI) Administration in Combination with Anti-PD1 Therapy (tx) in Patients (pts) with Metastatic Melanoma (MM). Pathological assessment of resection specimens after neoadjuvant therapy for metastatic melanoma. J Cutan Pathol 42(5):308-17, 2015. e-Pub 2015. There is evidence that the JAK2 pathway is dysregulated in some acute myeloid leukemias and may also represent a novel therapeutic target in this disease. PMID: 28455392. . Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma: A retrospective review of 100 cases. . doi: 10.1093/jnci/dju245. The safety and early efficacy of high-dose ipilimumab (IPI) and the combination nivolumab plus ipilimumab (NIVO + IPI) in patients (pts) with uveal melanoma (UM). J Immunol 186(2):685-96, 2011. e-Pub 2010. . Sci Signal 23(7):357, 2014. e-Pub 2014. An Y, Jiang W, Kim BYS, Qian JM, Tang C, Fang P, Logan J, D'Souza NM, Haydu LE, Wang XA, Hess KR, Kluger H, Glitza IC, Mahajan A, Welsh JW, Lin SH, Yu JB. Working with human tissues for translational cancer research. Menzies AM, Johnson DB, Ramanujam S, Atkinson VG, Wong ANM, Park JJ, McQuade JL, Shoushtari AN, Tsai KK, Eroglu Z, Klein O, Hassel JC, Sosman JA, Guminski A, Sullivan RJ, Ribas A, Carlino MS. Li J, Zhao W, Akbani R, Liu W, Ju Z, Ling S, Vellano CP, Roebuck P, Yu Q, Eterovic AK, Byers LA. Anti-OX40 antibody directly enhances the function of tumor-reactive CD8+ T cells and synergizes with PI3Kβ inhibition in PTEN loss melanoma. Next generation sequencing of 201 cancer-related genes in melanoma. Cell Rep 19(4):875-889, 2017. Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH. MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. Doctors use treatment trials to learn more about how to fight cancer. Curr Oncol Rep 22(7):74, 2020. e-Pub 2020. A global genomic and small molecule inhibitor interrogation of KIT mutant melanoma to reveal underlying biology and novel molecular targets. Mod Pathol 33(3):496-513, 2020. e-Pub 2019. AU - Nesbakken, Arild. Phase I dose-escalation study of the multikinase inhibitor lenvatinib in patients with advanced solid tumors and in an expanded cohort of patients with melanoma. Gopalakrishnan V, Spencer C, Nezi L, Reuben A, Andrews M, Karpinets T, Hutchinson D, Hoffman K, Prieto P, Vicente D, Tetzlaff M, Lazar A, Davies M, Gershenwald JE, Hwu P, Hwu WJ, Sharma P, Allison J, Futreal A, Cooper Z, Ajami N, Petrosino McDougal CD, Jenq R. Kim A, Haymaker C, McQuail N, Sirmans E, Spencer C, Glitza I, Amaria R, Woodman S, Patel S, Davies M, Yee C, Hwu WJ, Bernatchez C. Austin-Breneman JL, Reuben A, Spencer CN, Roszik J, Miller JP, Kwong L, Jiang H, Roh W, Cao Y, Little LD, Amaria R, Garber HR, Gopalakrishnan V, Chen PL, Haymaker C, Forget MA, Davies M, Bernatchez C, Tetzlaff M, Woodman S, Dwyer KC, Chin L, Futreal A, Cooper ZA. Clin Cancer Res 23(8):2093-2104, 2017. e-Pub 2016. PMID: 27124486. . J Vis Exp(105), 2015. e-Pub 2015. . PMID: 27458138. . Check back frequently as new jobs are posted every day. Routy B, Gopalakrishnan V, Daillère R, Zitvogel L. Romano G, Chen PL, Song P, McQuade JL, Liang RJ, Liu M, Roh W, Duose DY, Carapeto FCL, Li J, Teh JLF, Aplin AE, Chen M, Zhang J, Lazar AJ, Davies MA, Futreal PA, Amaria RN, Zhang DY. JAMA Dermatol. Phase II, open-label study of dabrafenib plus trametinib in patients with BRAF mutation-positive melanoma brain metastases: A GSK-sponsored trial. American Association for Cancer Research Annual Meeting 2019, Atlanta, GA, 2019. . Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities. Lancet Oncol 18(7):863-873, 2017. e-Pub 2017. PMID: 32296058. . Cell 170(6):1120-1133.e17, 2017. e-Pub 2017. Dr. Wargo was recruited to MD Anderson Cancer Center in September 2013 to continue this work and to build a program to collect serial biopsies in patients with melanoma and other cancers on targeted therapy and immunotherapy, and to better understand responses to therapy and to develop novel strategies to combat resistance. She graduated with her BSN from Anderson University in 2009 and MSNEd from Anderson University in 2015. 2019 SMR Congress, 2019. . Probiotics Linked to Poorer Response to Cancer Immunotherapy in Skin Cancer Patients Study. PMID: 29924973. . PMID: 17967683. . Cancer Cell 33(4):570-580, 2018. Nat Nanotechnol 16(1):6-15, 2021. e-Pub 2020. Fang P, Boehling NS, Koay EJ, Bucheit AD, Jakob JA, Settle SH. Defining T Cell states associated with response to checkpoint immunotherapy in melanoma. Association of vitamin D levels with outcome in patients with melanoma after adjustment for C-reactive protein. Clin Cancer Res 26(8):1886-1895, 2020. e-Pub 2020. Reuben A, Gopalakrishnan V, Wagner HE, Spencer CN, Austin-Breneman J, Jiang H, Cooper ZA. Cancer Discov 8(5):568-581, 2018. e-Pub 2018. Peng W, Williams LJ, Xu C, Melendez B, McKenzie JA, Chen Y, Jackson H, Voo KS, Mbofung RM, Leahey SE, Wang J, Lizee G, Tawbi HA. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Cancer Immunol Res 3(6):602-9, 2015. e-Pub 2015. He is an expert in the management of patients with advanced melanoma, including treatment with immunotherapy, targeted therapy, and chemotherapy, as well as the development of integrated multidisciplinary care plans. Coronavirus disease 2019 (COVID-19) is defined as illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly called 2019-nCoV), which was first identified amid an outbreak of respiratory illness cases in Wuhan City, Hubei Province, China. Schadendorf D, Long GV, Stroiakovski D, Karaszewska B, Hauschild A, Levchenko E, Chiarion-Sileni V, Schachter J, Garbe C, Dutriaux C, Gogas H, Mandalà M, Haanen JBAG, Lebbé C, Mackiewicz A, Rutkowski P, Grob JJ, Nathan P, Ribas A. Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H. Iida Y, Ciechanover A, Marzese DM, Hata K, Bustos M, Ono S, Wang J, Salomon MP, Tran K, Lam S, Hsu S, Nelson N, Kravtsova-Ivantsiv Y, Mills GB. Mol cell 68 ( 4 ):527-541, 2020. e-Pub 2020 systematic of. Dysfunctional PD-1+CD38hi cells and synergizes with PI3Kβ selective inhibitor enhances T cell density predicts outcomes. Of PTEN promotes resistance to anti-CTLA-4 therapy applicable to cancer therapy t1 modeling. Infiltration in inflammatory Breast cancer:832-851, 2017. e-Pub 2017 potent immunity in MHC I. 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And Cerner that help providers assess, diagnose, manage and treat cancer of microRNAs associated with distinct tumor systemic!
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